5 mg orally daily. Letrozole Uses . Introduction For Lezra Excel 2. Estrogen use with letrozole: use other options for conditions in which estrogen is indicated. Continuous data were compared with the use of Student t test and categoric variables with the use of χ 2 test. Fortunately, it is possible to become pregnant with PCOS. 6. Aromasin is a kind of endocrine therapy. 2). • Letrozole (LET-roe-zole) is a drug that is used to treat breast cancer. 5’ on other side. The right time to start taking letrozole is on the third or fourth day of your menstrual cycle. 2. If you have questions about side effects, call your doctor. Cytostatic. 5mg 2. found. 5) 0 (0. 5mg. and R$50 - R$300 in Brazil. It prevents the recurrence of cancer. 4 CONTRAINDICATIONS. Hot flushes can sometimes occur. vision changes. It is on the World. We undertook a retrospective review of over 900 treatment cycles using letrozole in doses. 5 mg Film-coated tablets should only be used in women with a clearly established postmenopausal status (see section 4. Letrozole is a long-term treatment so you may have to take it for several years. Ovarian stimulation by follicle-stimulating hormone (FSH) is routinely used in IVF and the resulting high serum estradiol levels may impair oocyte/embryo quality and endometrial receptivity. Early-stage, hormone receptor–positive (HR+) breast cancer that has been treated. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (MHRD) on a mg/m 2 basis. 2 Use in Adjuvant Treatment of Early Breast. Lez-T Letrozole 2. Brand name: Femara Drug class: - Aromatase Inhibitors VA class: AN900 Chemical name: 4,4′-(1H-1,2,4-triazol-1-ylmethylene)bis-benzonitrile Molecular formula: C 17 H 11 N 5 CAS number: 112809-51-5 Medically reviewed by Drugs. Letrozole may be mainly used to treat breast cancer patients. Purpose Previous analyses of the Breast International Group (BIG) 1-98 four-arm study compared initial therapy with letrozole or tamoxifen including patients randomly assigned to sequential treatment whose information was censored at the time of therapy change. 5 mg once daily for a planned duration of 5 years; discontinue at relapse. Lezra tablet 2. View Lez 2. e. Letrozole tablet uses in hindi, letrozole tablet - Buy anabolic steroids onlineAlso, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Letrozole is a hormone therapy drug used to treat breast cancer in women who've gone through a natural menopause (when periods stop). Moreover, the co-administration of gonadotropin and letrozole enhances outcomes in normal responders going through IVF cycles (13-15). , during the weekend, or on a holiday, call 212-639-2000. 4 CONTRAINDICATIONS. Femara is a brand (trade) name for letrozole. Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. 1% taking tamoxifen; this was highly significant . If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. Letrozole is used to treat breast cancer in postmenopausal women. A manual pellet press was used to compress the triturate into 3. Adjuvant therapy for postmenopausal women with hormone receptor positive early breast cancer, Advanced breast cancer in postmenopausal women. Note: “During treatment” includes 30 days after last dose. Composition: Lezra excel contains 2. 007). Letrozole is also used to help prevent the cancer. , pain or burning sensation in the hands or wrists) decreased sense of touch. Even today, it is commonly used as a first-line treatment. It is also used to help prevent cancer recurrence. and R$3. 4% after FET with letrozole and 50. High cholesterol, joint pain, and bone loss are also possible. Countries. 5 mg, taken cycle days 3-7). May 29, 2022. increased cholesterol in your blood. Levalbuterol comes as a solution (liquid) to inhale by mouth using a nebulizer (machine that turns medication into a mist that can be inhaled), a concentrated solution to be mixed with normal saline and inhaled by mouth using a nebulizer, and as an aerosol to inhale by mouth using an inhaler. 5 mg tablet administered once a day, regardless to meals. Clomid or letrozole have 4 - 9% live birth rates, 1 - 13% of pregnancies result in multiples, and costs can be as low as $500 in the U. Some breast cancers are made to grow faster by a natural hormone called estrogen. . If you're a patient at MSK and you need to reach a provider after 5 p. In the extended adjuvant setting, the optimal treatment duration with letrozole tablets is not known. Letrozole was developed after Arimidex but before Aromasin, and it is the strongest and most potent of the three aromatase inhibitors by far. It is used for treating ERα-positive local or metastatic breast cancer in postmenopausal women. They’re commonly prescribed for people with polycystic ovary syndrome (PCOS) or unexplained infertility. sudden speech problems. Hot flashes and night sweats. sudden loss of coordination. 6-Word Stories. 5 Tablet is used in the treatment of Breast cancer,Infertility due to anovulation. What is the effect of letrozole use in patients undergoing frozen embryo transfer (FET) with normal ovulation? Although the number of FETs is increasing, an optimal protocol for FET (particularly vitrified–warmed embryo transfer) is yet to be determined. Weight gain or loss. What side effects can Letrozole cause? Bone pain, joint pain or muscle ache. It can also be given as a sequential treatment; 2 years of Letrozole followed by 3 years of tamoxifen. Letrozole has a short half-life and has both peripheral and central effects (12, 13). 👉 Letrozole dosage, letrozole uses - Buy anabolic steroids online Letrozole dosage If users want to run testosterone during a cutting cycle, but with minimal water weight, an anti-estrogen such as anastrozole or letrozole can be. Because fatigue, dizziness, and somnolence have been reported with the use of letrozole, caution is advised when driving or using machinery until it is known how the patient reacts to letrozole use. It is used for estrogen receptor-positive breast cancers [1, 2]. Letrozole, an aromatase inhibitor,. (AJOG, 2021) assessed the impact of letrozole (an aromatase inhibitor) during frozen embryo transfer (FET) on obstetrical and perinatal outcomes of singleton and twin pregnancies compared with artificial cycle FET among women with polycystic ovary syndrome METHODS: Retrospective cohort study Participants Women with PCOS undergoing FET from 2010 to […] pain in the chest, groin, or legs, especially the calves. 5. It is used in postmenopausal women for the adjuvant treatment of early breast cancer, for extended adjuvant therapy after 5 years of tamoxifen, and for the treatment of advanced breast cancer. Objective: The object of this study was to evaluate the efficacy of letrozole co-treatment with GnRH-antagonist protocol in ovarian stimulation of poor responder patients undergoing intracytoplasmic sperm injection. 1 Bone Effects. If you have recently gone through menopause, discuss the need for use of reliable forms of birth control while taking this medication and for 3 weeks after stopping treatment with your doctor. 2. Introduction. 5’ on other side. 2 Use of Lez-T and Food: The tablet can be taken with or without food. Use of letrozole may cause decreases in bone mineral density (BMD). Bundred N, Campbell I, Coleman R, et al: Zoledronic acid in the prevention of cancer treatment-induced bone loss in postmenopausal women receiving letrozole as adjuvant therapy for early breast cancer (ZO-FAST study). Aromasin contains the active drug exemestane. 5 mg Tablets Lez-T Letrozole Tablets Composition: Active ingredient: Each film-coated tablet contains: Letrozole 2. 2. Peripheral oedema, chest pain. It was banned in India in 2011 due to potential risk to infants. In animal models of breast cancer, acquired resistance to letrozole can be reversed by discontinuing treatment, suggesting a strategy of alternating “on-off” letrozole treatment as a therapeutic option to prolong sensitivity to endocrine therapy. Letrozole Post-cycle therapy is a critical phase that aims to restore hormonal balance, enhance natural testosterone production, and mitigate any potential side effects of a cycle. Women who don’t ovulate (anovulation), have absent or irregular menstrual cycles, or have been diagnosed with PCOS, the most common ovulatory disorder affecting one in ten women, often require medications to conceive. 1) Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant tamoxifen therapy. An alternative schedule of extended adjuvant endocrine therapy with letrozole, including intermittent administration, might be feasible and the. 5 MG Tablet may cause side effects such as tiredness, loss of. New research out from epidemiologist Dr. However, dose administration has generally been limited to 5 days at 2. Thus, letrozole was expected to have a potential of improving luteal function and outcome in patients with advanced maternal age. Letrozole (Femara) is type of hormone therapy called an aromatase. Letrozole is used to treat certain types of breast cancer in women who have already stopped menstruating (postmenopausal). 97 kg were used for the study. Methods Our retrospective cohort included all LTZ-FET (n = 161) and NC-FET (n = 575) cycles that transferred a single euploid autologous blastocyst from 2016 to 2020 at Stanford Fertility Center. 12+ months is a very long time to be continuing letrozole with no success. Pain, redness/discolouration, heat and swelling of the arm or leg. Use of letrozole may cause decreases in bone mineral density (BMD). Bahan-bahan lain yang terkandung di dalamnya adalah laktosa monohidrat, selulosa mikrokristalin (E460), pati jagung yang dipragelatinisasi, natrium pati glikolat, magnesium stearat (E572), silikon dioksida koloid (E551). The growth of some breast cancers in postmenopausal women is. It works by lowering the amount of estrogen the body produces. 16. Clomid (Clomiphene citrate) has been the most commonly prescribed oral fertility drug for over 50 years. Aromasin is a brand-name prescription medication. Arimidex vs. Consideration should be given to monitoring BMD. Letrozole is typically used in postmenopausal women who have already undergone other treatments for breast cancer. Complete Hemogram (CBC & ESR) Letzol 2. Clinical particulars. the study. Cytostatic. Letrozole works by blocking the action of the enzyme aromatase, which prevents the body from converting androgens into estrogens. When compared to megestrol, lower weight gain and vaginal bleeding have been observed with letrozole, but higher incidences of hot flashes, headache, rash, nausea, musculoskeletal pain, other. PURPOSE: To compare the efficacy and tolerability of tamoxifen with that of letrozole, an oral aromatase inhibitor, with tamoxifen as first-line therapy in postmenopausal women with advanced breast cancer. slurred speech. They had all already been through the menopause. Dosing: Adult. Letrozole Tamoxifen; It is also known as Femara, an aromatase inhibitor used in the treatment of hormonally-responsive breast cancer following surgery. How does Letrozole (Femara) work? Letrozole is commonly prescribed to treat conditions impacted by estrogen levels, such as certain types of breast cancer. If this occurs, take your tablets at bedtime. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. how to use lezra excel 2. Letrozole belongs to a group of drugs called Aromatase Inhibitors that prevents the conversion of Androgen to Estrogen in women. Letrozole belongs to a group of drugs called Aromatase Inhibitors that prevents the conversion of Androgen to Estrogen in women. Letrozole Accord reduces the amount of estrogen by blocking an. Letrozole reduces the amount of estrogen by. Letrozole inhibits the production of Estrogen and thus prevents the growth of a Tumor. Modify Therapy/Monitor Closely. Decreased breast cancer risks. Anastrozole is an aromatase inhibitor []. 5 Tablet is used for Breast Cancer etc. We aimed to determine whether poor/sub-optimal responders might benefit from Letrozole co-treatment throughout the entire stimulation course. Letrozole is also used to help. Guideline-Supported Use. 5mg) Letrozole belongs to a class of drugs known as nonsteroidal aromatase inhibitors. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2 to L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median. Letrozole tablets may cause fetal harm when administered to a pregnant woman and the clinicl benefit to premenopausal women with breast cancer has not been demonstrated. 008) at 24. #lezraexcelta. Selet 2. Lez-T reduces the amount of estrogen by blocking an enzyme (“aromatase”) involved in the production of estrogens and may therefore block the growth of breast cancers that need. nausea. Lezra tablet contains Letrozole | belongs to Non-steroidal aromatase inhibitor. It’s produced mainly by adrenal glands as well as the testicles. Letrozole Stada reduces the amount of estrogen by blocking an. Lezra is used to treat postmenopausal breast cancer. Letrozole is a prescription drug is used to treat certain types of breast cancer (such as hormone-receptor-positive breast cancer) in women after menopause. Letrozole inhibits the liver enzyme CYP2A6, and to a lesser extent CYP2C19, in vitro, but no relevant interactions with drugs like cimetidine and warfarin have been observed. It works by blocking the effect of androgens. Aromatase inhibitors work by inhibiting the action of the enzyme aromatase, which converts androgens into estrogens by a process called aromatization. 2 Extended Adjuvant Treatment of Early Breast Cancer. Results. Femara (letrozole) is indicated for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. 5 MG Tablet (10) online & get Flat 15% OFF on PharmEasy. vaginal dryness or irritation. Reiki. Lesbians are kinkier and druggier. Background Letrozole, or CGS 20267, is an oral non-steroidal type II aromatase inhibitor first described in the literature in 1990. 1 Bone Effects Use of Femara may cause decreases in bone mineral density (BMD). Some studies have found an increased risk of certain cancers if Clomid is used more than six times without a pregnancy success, and Clomid can also thin the uterine lining Therefore, if Clomid or Femara doesn’t work after. Filter by condition. There were also twice as many cardiac deaths with letrozole than with tamoxifen (13 vs. For vaginal complaints such as dyspareunia, dryness and sexual dysfunction, topical estrogen may be considered. 06 to 1. Swelling, redness or tenderness where a central line is inserted to give chemotherapy - for example in the arm, chest area or up into the neck. : Letrozole use during frozen embryo transfer cycles in women with polycystic ovary syndrome. Letrozole is used mainly in women after menopause. 5 mg tablets: yellow round, biconvex, film coated tablets imprinted with 'LT' on one side and plain on other side. It works by decreasing the amount of estrogen hormone your body makes, which slows or. Fertil Steril. Geranium: has an overall balancing effect on female hormones. Togas Tulandi at McGill University to propose a multicenter Canadian study designed to compare birth outcomes in women conceiving after the use of CC or letrozole. 5 MG Tablet (30) online & get Flat 15% OFF on PharmEasy. No experience with letrozole overdose has been reported. It has been prescribed by fertility doctors since the early 2000s. Femara (letrozole) is an oral medication used to stimulate ovulation in people with polycystic ovary syndrome (PCOS) and unexplained infertility. Clomid and Letrozole have emerged as go-to options for individuals seeking effective PCT strategies. pain in the chest, groin, or legs, especially the calves. , 2014 ; Li et al . An RE could monitor you pre/post ovulation to check your follicles, hormones, etc to see if everything is working correctly. This is not a complete list of side effects and others may occur. 5mg. According to the latest guidelines, letrozole should be considered as the first-line pharmacological treatment for women with WHO Group II anovulation or PCOS. Take with food if it causes an upset stomach. 16. Official answer. This drug can also be used to prevent breast cancer from recurring. flushing (temporary warmth, redness. m. Femara is indicated for the extended adjuvant treatment of early breast cancer in postmenopausal women, who have received 5 years of adjuvant. 5. It sounds like your OB isn’t monitoring you. Despite this growing use, our understanding of the impact of letrozole on pregnancy outcomes in FET cycles is still in the early stages. There is limited information regarding Off-Label Guideline-Supported Use of Letrozole in adult patients. If tiredness is a problem, do not drive a car or operate machinery if you are feeling tired. However, the ovarian follicle’s response to FSH is only a part of the endocrine events. Adult: In hormone receptor +ve postmenopausal women: 2. Letrozole is an aromatase inhibitor indicated for: Adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Novartis had manufactured the drug after it was approved for sale on the American prescription drug market in 1997, and was sold as the brand name Femara as well as a separate brand name Femar in certain other select countries across the world (mostly in. Procedure. This medicine is available only with your doctor's prescription. So letrozole can be used alongside Clomid as another way to increase the chances of conception. Weight gain or loss. This medication is used to treat certain types of breast cancer (such as hormone -receptor-positive breast cancer) in women after menopause. The enthusiasm over letrozole’s potential grew even more following the completion of a successful in-house phase 1 study in healthy male volunteers, which used a letrozole solution instead of tablets in order to speed up the development process . Do not use birth control products containing estrogen. Female hormones that occur naturally in the body can increase the growth of some breast cancers. Another earlier study looked at lesbian women ranging in age from 26-44 and single women age 29-47 using frozen sperm and found a clinical pregnancy rate of 57% in lesbians and 36% in single women. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. Women who have been struggling to conceive may find that. No dose adjustment is required for elderly patients. Lethality was observed in mice and rats following single oral doses that were greater than or equal to 2000 mg/kg (~4000 to 8000 times the maximum daily doses recommended in humans); death was associated. When used as a. A first- and second-line treatment for hormone receptor positive or unknown advanced breast cancer. Below is a text only representation of the Patient Information Leaflet (ePIL). By 10 p. This can result in ovulation. You are advised to take LETROZOLE for as long as your doctor has prescribed it for you depending on your medical condition. What is this medication? LETROZOLE (LET roe zole) treats some types of breast cancer. Letrozole, also known by its brand name Femara, is an oral medication used to stimulate egg development and ovulation in female patients undergoing fertility treatment . Treatment may be continued up to 5 yr for extended adjuvant therapy or until tumour progression for. 025) and a. Advise pregnant women of the. Consideration should be given to monitoring BMD. letrozole. In Menopausal Women, the Ovaries do not produce Estrogen. Weight change in post‐menopausal women with breast cancer during chemotherapy‐perspectives on. This medicine may increase the risk of fractures. Know Letroz 2. 1. Chris Li and others at the Hutch now suggests bisphosphonates may. Femara (letrozole) is a brand-name prescription drug used for certain types of breast cancer. 1 Bone Effects. Lez-T Tablets. how to use lezra excel 2. In the extended adjuvant setting, the optimal treatment duration with letrozole tablets is not known. The recommended dose is one 2. 5 mg 30’s is used in the treatment of breast cancer in postmenopausal women. DesignRetrospective observational study. com on May 25, 2023. Letrozole is also being studied in the. Animals were randomly divided into two equal groups and subcutaneously received either 0. Common Femara side effects may include: hot flashes, warmth or redness in your face or chest; headache, dizziness, weakness; bone pain, muscle or joint pain; swelling, weight gain; increased sweating; or. You may also hear it called Femara, which is its best-known brand name. 71 and −3. Early-stage breast cancer that has been treated with tamoxifen citrate for at least 5 years. A single-blind, crossover trial of 72 women whose HR+ breast cancer progressed on tamoxifen were randomized to either letrozole or anastrozole for four weeks and then crossed over to the other AI for another 4 weeks found significantly less reported joint pain in the letrozole arm than the anastrozole arm (3% vs 11%; p=0. I am on year 8 taking Letrozole. 1. It belongs to a group of medicines called aromatase inhibitors. Whenever possible, give letrozole to yourself and follow the steps below. Although anti‐oestrogens tamoxifen and letrozole have been used for more than a decade, less is known about the side effects of these treatments on thyroid function. Consideration should be given to monitoring BMD. The text only version may be available in large print, Braille or audio CD . #lezraexcelta. However, their study did not account for multiple. Letrozole is an anticancer agent which is used in the treatment of breast cancer. After 6 cycles of IUI, cumulative rates were 70% and 47%, respectively. Know it’s uses, side effects, reviews, composition and precautions only on 1mg. Treatment should be discontinued at tumor relapse. pain in the chest, groin, or legs, especially the calves. It can also cause more fatigue (lack of energy). The Institute compared the effects of aromatase inhibitors used in this way with the effects of no treatment or a placebo treatment. Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. 6 vs. It is also used off-label for the treatment of infertility, idiopathic short stature in boys, and. Effective use of letrozole for ovulation induction, in women with an inadequate response to CC, was first described by Mitwally and Casper in 2001. Consideration should be given to monitoring BMD. Introduction In vitro fertilisation (IVF) is an effective infertility treatment but the live birth rate remains unsatisfactory. The results have been reported as Mean ± SD, frequencies and percentages. We randomly assigned women (1:1) to treatment groups of either continuous use of letrozole (2·5 mg/day orally for 5 years) or intermittent use of letrozole (2·5 mg/day orally for 9 months. Letrozole is used in the treatment of breast cancer and infertility due to anovulation. Letrozole inhibits the production of Estrogen and thus prevents the growth of a Tumor. Complete Hemogram (CBC & ESR) Letzol 2. It is a hormonal (or "endocrine") treatment for breast cancer. Not able to sleep. It works by decreasing the amount of estrogen hormone your body makes, which slows or stops breast cancer cells from spreading or growing. sudden, severe weakness or numbness in the arm or leg. The procedure itself involves transferring semen that has been washed and concentrated directly into the uterus via a. letrozole, severely impaired hepatic function, uncontrolled hypertension and thromboembolism. 25 mg/kg BW of letrozole or a control every week for 2 months. By the data cutoff date for the final analysis (February 26, 2016), a total of 331 events of disease progression or death had occurred (194 [43. Letrozole. Letrozole is also used to induce ovulation in women who exhibit polycystic ovary syndrome or anovulation. Letrozole, also known by its brand name Femara, is an oral medication used to stimulate egg development and ovulation in female patients undergoing fertility treatment . 7% with artificial-cycle FET (P =. 5. We believe, in the light of the accumulating clinical research evidence, that letrozole is safe for use in assisted reproduction. swelling of the feet or lower legs. The Letrozole fertility results are great. fertnstert. When these treatments are unsuccessful, your provider may recommend gonadotropins or surgery. It is a selective aromatase inhibitor that blocks oestrogen biosynthesis and indirectly increases pituitary secretion of follicle-stimulating hormone (FSH), thus increasing FSH stimulation to the ovary and promoting follicular development (). 0) Unexplained: 34 (21. Consideration should be given to monitoring BMD. Letrozole. Many cancers are hormone sensitive (estrogen or progesterone receptor positive) and their growth can be affected by lowering estrogen levels in the body. Belly pain. For vaginal complaints such as dyspareunia, dryness and sexual dysfunction, topical estrogen may be considered. These include diarrhea, belly pain, and nausea. 5. give letrozole to you, they also need to follow these steps: 1. 100% authentic medicine with nationwide delivery. Results of a safety study to evaluate safety in the adjuvant setting comparing the effect on lumbar spine (L2-L4) BMD of adjuvant treatment with letrozole to that with tamoxifen showed at 24 months a median decrease in lumbar spine BMD of 4. The risk of getting Ovarian Hyperstimulation Syndrome is associated with the fertility drugs used in IUI like Letrozole and Clomid to stimulate ovulation. ( 1. These compounds were also used to design pioneering molecular modeling techniques used to map the active site of aromatase [ 70 , 72 ]. com. It’s prescribed for adult females* who’ve gone through. 5mg tablet is composed of Letrozole (2. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (MHRD) on a mg/m 2 basis. It is a hormonal (or “endocrine”) treatment for breast cancer. Not able to sleep. 41); after adjusting for confounding factors, live birth rate was consistently higher in the letrozole group. Like all medications, letrozole can cause side effects. Super Quick Home Delivery with COD No Minimum Order Value Pan India Delivery. Letrozole is a highly effective aromatase inhibitor. com. 1. Therefore, letrozole treatment is considered an effective option in endometrial preparation for FET in patients with ovulation disorders or irregular menstruation. It only works in women who are post-menopausal and producing estrogen outside the ovaries. 2. In fact, with Clomid, having more than six cycles is discouraged (a max of three to four is recommended). Print. Timed intercourse is essentially, just like it sounds; a couple engages in intercourse a few days before ovulation which allows the sperm just enough time to swim through the uterus and into the. Anastrozole competitively inhibits the aromatase enzyme, which synthesizes estrogen [1, 2]. 5 MG Tablet is a medicine used in the treatment of breast cancer in postmenopausal women (women who have not had periods for more than a year marking the end of menstrual cycles). Bone pain, joint pain or muscle ache . Due to the promising preclinical and phase 1 results, and once again to shorten development. 5 mg are dark yellow coloured, round, biconvex, film coated tablets with ‘LET’ debossed on one side and ‘2. When the enzyme. It. swollen glands. Typical dosage. Letrozole is also used to help prevent the cancer from returning. 18, 95% CI 1. Some forms of cancer cells of breast that require estrogen to proliferate can be slowed or stopped by this. Doctors usually recommend women to take around 2.